On Wednesday, October 12, 2022, at approximately 1:20 PM, the Mississippi Highway Patrol responded to a fatal crash on Highway 43 in Hancock County. A 2004 Chevrolet Trailblazer driven by Larry Margerum, 72, of Picayune, MS, was traveling North on Highway 43. The vehicle left the roadway and overturned. Larry Margerum received fatal injuries from the crash.

The cause of the crash is under investigation by the Mississippi Highway Patrol.